Author: Sisi Li, Wenzhan Tu, Chengqian Jia, Xia Jiang, Xinru Qian, Guanhu Yang, Qimiao Hu, Wenci Chen, Bin Lu, and Songhe Jiang Abstract: Potassium‑chloride cotransporter 2 (KCC2) has been indicated to serve a crucial role during chronic neuropathic pain (NP). Following the emergence of NP, γ ‑aminobutyric acid (GABA) A receptor‑mediated signaling may be further impaired by the changes of KCC2 chloride anion gradient. In the present study, the authors investigate the effect